Commentary: EPA's proposed expansion of dose-response analysis is a positive step towards improving its ecological risk assessment

TitoloCommentary: EPA's proposed expansion of dose-response analysis is a positive step towards improving its ecological risk assessment
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2019
AutoriAgathokleous, E., Anav A., Araminienė V., De Marco Alessandra, Domingos M., Kitao M., Koike T., Manning W.J., Paoletti E., Saitanis C.J., Sicard P., Vitale M., Wang W., and Calabrese E.J.
RivistaEnvironmental Pollution
Paginazione566-570
ISSN02697491
Parole chiavecommunity, controlled study, decision making, dose response, Dose-Response Relationship, Drug, Ecological risk assessment, Ecology, ecosystem health, environmental policy, government, government regulation, Hormesis, human, Humans, legislation and jurisprudence, Nonlinear Dynamics, nonlinear system, note, procedures, Risk assessment, spatial analysis, statistics and numerical data, temporal analysis, United States, United States environmental protection agency
Abstract

The United States Environmental Protection Agency (US EPA) has recently proposed changes to strengthen the transparency of its pivotal regulatory science policy and procedures. In this context, the US EPA aims to enhance the transparency of dose-response data and models, proposing to consider for the first time non-linear biphasic dose-response models. While the proposed changes have the potential to lead to markedly improved ecological risk assessment compared to past and current approaches, we believe there remain open issues for improving the quality of ecological risk assessment, such as the consideration of adaptive, dynamic and interactive effects. Improved risk assessment including adaptive and dynamic non-linear models (beyond classic threshold models) can enhance the quality of regulatory decisions and the protection of ecological health. We suggest that other countries consider adopting a similar scientific-regulatory posture with respect to dose-response modeling via the inclusion of non-linear biphasic models, that incorporate the dynamic potential of biological systems to adapt (i.e., enhancing positive biological endpoints) or maladapt to low levels of stressor agents. © 2018 Elsevier Ltd EPA proposed changes in its regulatory science that can improve ecological risk assessment and increase protection of ecological health. © 2018 Elsevier Ltd

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85059066906&doi=10.1016%2fj.envpol.2018.12.046&partnerID=40&md5=28e0537ba35e4db8ea4ebdbc20cd0f6d
DOI10.1016/j.envpol.2018.12.046