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The Cosmic Silence experiment: On the putative adaptive role of environmental ionizing radiation

TitoloThe Cosmic Silence experiment: On the putative adaptive role of environmental ionizing radiation
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2009
AutoriCarbone, M.C., Pinto M., Antonelli Francesca, Amicarelli F., Balata M., Belli M., L. Devirgiliis Conti, Ioannucci L., Nisi S., Sapora O., Satta L., Simone G., Sorrentino E., and Tabocchini M.A.
RivistaRadiation and Environmental Biophysics
Volume48
Paginazione189-196
ISSN0301634X
Parole chiaveAdaptive response, aerobic metabolism, Agents, Animal cell culture, Antioxidants, article, Background Radiation, biochemistry, cancer cell culture, Catalase, cell culture, Cell Line, cell proliferation, Central Italy, Chinese hamsters, controlled study, Cosmology, Cricetulus griseus, DNA damage, DNA damages, Dose-Response Relationship, dosimetry, environmental exposure, Environmental radiations, enzyme activity, Genotoxic agents, genotoxicity, growth curve, growth rate, human, human cell, Human cell lines, Humans, in vitro study, In-vitro, Ionizing, Ionizing radiation, Low dose rates, lymphoblastoid cell line, Lymphocytes, micronucleus test, Micronucleus Tests, Nucleic acids, Oxidative metabolisms, Radiation, radiation dose, Radiation shielding, radioactivity, radiometry, Underground laboratories, V79-cells, X ray, X-Rays
Abstract

Previously we reported that yeast and Chinese hamster V79 cells cultured under reduced levels of background environmental ionizing radiation show enhanced susceptibility to damage caused by acute doses of genotoxic agents. Reduction of environmental radiation dose rate was achieved by setting up an underground laboratory at Laboratori Nazionali del Gran Sasso, central Italy. We now report on the extension of our studies to a human cell line. Human lymphoblastoid TK6 cells were maintained under identical in vitro culture conditions for six continuous months, at different environmental ionizing radiation levels. Compared to "reference" environmental radiation conditions, we found that cells cultured in the underground laboratories were more sensitive to acute exposures to radiation, as measured both at the level of DNA damage and oxidative metabolism. Our results are compatible with the hypothesis that ultra-low dose rate ionizing radiation, i.e. environmental radiation, may act as a conditioning agent in the radiation-induced adaptive response. © 2009 Springer-Verlag.

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cited By 16

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-63849173930&doi=10.1007%2fs00411-008-0208-6&partnerID=40&md5=ce2101fd53ec0de2a6c89290877ff253
DOI10.1007/s00411-008-0208-6
Citation KeyCarbone2009189