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Murine recombinant interleukin-3 induces recovery of T and B cells in irradiated mice

TitoloMurine recombinant interleukin-3 induces recovery of T and B cells in irradiated mice
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione1994
AutoriFrasca, D., Leter Giorgio, and Doria G.
RivistaBlood
Volume83
Paginazione1563-1568
ISSN00064971
Parole chiaveanimal, animal cell, animal experiment, animal model, animal tissue, Antigens, article, B lymphocyte, B-Lymphocytes, blood cell count, CD4, CD8, Cell Count, cell differentiation, cell function, cell proliferation, Cell Survival, controlled study, Female, immune system, Inbred C57BL, Inbred DBA, interleukin 3, Interleukin-3, irradiation, Lymphocyte Subsets, Mice, mitosis, mouse, nonhuman, priority journal, Recombinant Proteins, Spleen, T lymphocyte, T-Lymphocytes, thymocyte, thymus, Whole-Body Irradiation
Abstract

Injection of murine recombinant interleukin-3 (IL-3) into (C57BL/10 x DBA/2) F1 mice, sublethally irradiated with 300 cGy and killed 14 days later, induced in the thymus recovery of the cell number and mitotic responsiveness to concanavalin A (Con A), as well as an increase in number of double- negative CD4-CD8-, double-positive CD4+CD8+, and single-positive CD4+CD8- and CD4-CD8+ cells. Also in the spleen, the cell count and mitotic responsiveness to Con A and lipopolysaccharide were increased to normal levels by IL-3 treatment. If the assays were performed 21 or 28 days after irradiation, IL-3 treatment was able to restore thymus and spleen cell counts as well as T- and B-cell mitotic responsiveness, even when mice were exposed to 400 or 500 cGy, respectively. These results altogether indicate that IL-3 induces differentiation and growth of thymocytes and recovery of T- and B-cell functions in mice exposed to sublethal irradiation.

Note

cited By 5

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0028323184&partnerID=40&md5=7b0e6f340ad63a4f4850e90282f2e4c5
Citation KeyFrasca19941563