| Title | Murine recombinant interleukin-3 induces recovery of T and B cells in irradiated mice |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 1994 |
| Authors | Frasca, D., Leter Giorgio, and Doria G. |
| Journal | Blood |
| Volume | 83 |
| Pagination | 1563-1568 |
| ISSN | 00064971 |
| Keywords | animal, animal cell, animal experiment, animal model, animal tissue, Antigens, article, B lymphocyte, B-Lymphocytes, blood cell count, CD4, CD8, Cell Count, cell differentiation, cell function, cell proliferation, Cell Survival, controlled study, Female, immune system, Inbred C57BL, Inbred DBA, interleukin 3, Interleukin-3, irradiation, Lymphocyte Subsets, Mice, mitosis, mouse, nonhuman, priority journal, Recombinant Proteins, Spleen, T lymphocyte, T-Lymphocytes, thymocyte, thymus, Whole-Body Irradiation |
| Abstract | Injection of murine recombinant interleukin-3 (IL-3) into (C57BL/10 x DBA/2) F1 mice, sublethally irradiated with 300 cGy and killed 14 days later, induced in the thymus recovery of the cell number and mitotic responsiveness to concanavalin A (Con A), as well as an increase in number of double- negative CD4-CD8-, double-positive CD4+CD8+, and single-positive CD4+CD8- and CD4-CD8+ cells. Also in the spleen, the cell count and mitotic responsiveness to Con A and lipopolysaccharide were increased to normal levels by IL-3 treatment. If the assays were performed 21 or 28 days after irradiation, IL-3 treatment was able to restore thymus and spleen cell counts as well as T- and B-cell mitotic responsiveness, even when mice were exposed to 400 or 500 cGy, respectively. These results altogether indicate that IL-3 induces differentiation and growth of thymocytes and recovery of T- and B-cell functions in mice exposed to sublethal irradiation. |
| Notes | cited By 5 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028323184&partnerID=40&md5=7b0e6f340ad63a4f4850e90282f2e4c5 |
| Citation Key | Frasca19941563 |
