|Titolo||The impact of nanoparticle aggregation in liquid solution for toxicological and ecotoxicological studies|
|Tipo di pubblicazione||Articolo su Rivista peer-reviewed|
|Anno di Pubblicazione||2010|
|Autori||Miglietta, M.L., Rametta G., Di Francia G., Bruno A., De Lisio C., Leter Giorgio, Mancuso Mariateresa, Pacchierotti Francesca, Buono S., and Manzo Sonia|
|Rivista||Lecture Notes in Electrical Engineering|
|Parole chiave||Agglomeration, Aggregation kinetics, Aqueous solutions, Dynamic light scattering, Ecotoxicological study, Environmental release, Human exposures, In-vitro, Liquid solution, Microsystems, Nano-materials, Nanoparticle aggregation, Nanoparticles, Nanoscale particles, Nanostructured materials, Nanotechnology products, Optical engineering, Optical methods, Optical technique, Physico-chemical characterization, Potential hazards, Safety database, Sensors, Time resolved fluorescence polarization anisotropies, Time-scales|
Given the widespread applications of nanotechnology products, the evaluation of the potential hazards related to human exposures and environmental release of nanoparticles has become an urgent need. The development of a safety database for nanoscale particles is evolving as new particles, materials and exposure scenarios are being developed. Several studies have been focused on the importance of developing adequate physicochemical characterization of nanomaterials, in the relevant media being utilized, prior to undertaking experiments for in vitro and in vivo toxicity assessment. In this work we utilize two optical techniques: Dynamic Light Scattering (DLS) and Time Resolved Fluorescence Polarization Anisotropy (TRFPA) for measuring particle size, size distribution and aggregation kinetics of nanoparticles in aqueous solution for toxicological and ecotoxicological studies. The application of these two optical methods gives a careful description of the aggregation status of nanoparticles and its evolution on different time-scale. © 2010 Springer Science+Business Media B.V.
cited By 0; Conference of 14th Italian Conference on Sensors and Microsystems, AISEM 2009 ; Conference Date: 24 February 2009 Through 26 February 2009; Conference Code:80319