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The impact of nanoparticle aggregation in liquid solution for toxicological and ecotoxicological studies

TitleThe impact of nanoparticle aggregation in liquid solution for toxicological and ecotoxicological studies
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2010
AuthorsMiglietta, M.L., Rametta G., Di Francia G., Bruno A., De Lisio C., Leter Giorgio, Mancuso Mariateresa, Pacchierotti Francesca, Buono S., and Manzo Sonia
JournalLecture Notes in Electrical Engineering
Volume54 LNEE
ISBN Number9789048136056
KeywordsAgglomeration, Aggregation kinetics, Aqueous solutions, Dynamic light scattering, Ecotoxicological study, Environmental release, Human exposures, In-vitro, Liquid solution, Microsystems, Nano-materials, Nanoparticle aggregation, Nanoparticles, Nanoscale particles, Nanostructured materials, Nanotechnology products, Optical engineering, Optical methods, Optical technique, Physico-chemical characterization, Potential hazards, Safety database, Sensors, Time resolved fluorescence polarization anisotropies, Time-scales

Given the widespread applications of nanotechnology products, the evaluation of the potential hazards related to human exposures and environmental release of nanoparticles has become an urgent need. The development of a safety database for nanoscale particles is evolving as new particles, materials and exposure scenarios are being developed. Several studies have been focused on the importance of developing adequate physicochemical characterization of nanomaterials, in the relevant media being utilized, prior to undertaking experiments for in vitro and in vivo toxicity assessment. In this work we utilize two optical techniques: Dynamic Light Scattering (DLS) and Time Resolved Fluorescence Polarization Anisotropy (TRFPA) for measuring particle size, size distribution and aggregation kinetics of nanoparticles in aqueous solution for toxicological and ecotoxicological studies. The application of these two optical methods gives a careful description of the aggregation status of nanoparticles and its evolution on different time-scale. © 2010 Springer Science+Business Media B.V.


cited By 0; Conference of 14th Italian Conference on Sensors and Microsystems, AISEM 2009 ; Conference Date: 24 February 2009 Through 26 February 2009; Conference Code:80319

Citation KeyMiglietta201067