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Expression of B-myb in neuroblastoma tumors is a poor prognostic factor independent from MYCN amplification

TitoloExpression of B-myb in neuroblastoma tumors is a poor prognostic factor independent from MYCN amplification
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione1999
AutoriRaschellà, G., Cesi Vincenzo, Amendola R., Negroni Anna, Tanno Barbara, Altavista P., Tonini G.P., De Bernardi B., and Calabretta B.
RivistaCancer Research
Volume59
Paginazione3365-3368
ISSN00085472
Parole chiavearticle, cancer staging, cancer survival, Cell Cycle Proteins, Child, disease association, DNA-Binding Proteins, Follow-Up Studies, gene amplification, Gene expression, gene expression regulation, Genes, human, human cell, human tissue, Humans, Infant, major clinical study, Messenger, myc, Neoplasm, Neoplastic, Neuroblastoma, newborn, Oncogenes, Preschool, priority journal, prognosis, Proportional Hazards Models, Reverse Transcriptase Polymerase Chain Reaction, risk, RNA, Survival Analysis, Trans-Activators
Abstract

The transcription factors of the Myb family are expressed in several tissues and play an important role in cell proliferation, differentiation, and survival. In this study, the expression of A-myb, B-myb, and c-myb was investigated in a group of 64 neuroblastomas at different clinical stages by a sensitive reverse transcription-PCR technique and correlated with patients' survival. All of the myb genes were frequently expressed in neuroblastoma tumors. Interestingly, the expression of B-myb, which was detected in 33 cases, was associated with an increased risk of death (P = 0.027 in a univariate analysis), whereas there was no correlation with A-myb and c-myb expression. In addition, in a multivariate Cox regression analysis that included myb gene expression, MYCN status, age at diagnosis, and tumor staging, MYCN amplification and B-myb expression were independently associated to an increased risk (P < 0.01 and P = 0.015, respectively). In overall survival curves obtained by stratifying the neuroblastoma cases on the basis of MYCN status and B-myb expression, the group of patients without MYCN amplification and positive for B-myb expression had worse survival probability than that without MYCN amplification and nonexpressing B-myb (P < 0.01). In summary, these findings provide the first demonstration that B-myb expression can be a useful prognostic marker in human neuroblastoma. Moreover, B-myb expression has a prognostic value complementary to MYCN amplification and can identify a group of high-risk patients that would not be predicted on the basis of the MYCN status only.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0033565239&partnerID=40&md5=d75163265477e7e5c5c789f015f5f2a4
Citation KeyRaschellà19993365