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Radiation-induced DNA Damage and Repair in Lens Epithelial Cells of both Ptch1(+/-) and Ercc2(+/-) Mutated Mice

TitoloRadiation-induced DNA Damage and Repair in Lens Epithelial Cells of both Ptch1(+/-) and Ercc2(+/-) Mutated Mice
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2022
AutoriBarnard, S.G.R., McCarron R., Mancuso Mariateresa, De Stefano Ilaria, Pazzaglia Simonetta, Pawliczek D., Dalke C., and Ainsbury E.A.
RivistaRadiation research
Volume197
Paginazione36-42
ISSN19385404
Abstract

Epidemiological studies suggest an increased incidence and risk of cataract after low-dose (<2 Gy) ionizing radiation exposures. However, the biological mechanism(s) of this process are not fully understood. DNA damage and repair are thought to have a contributing role in radiation-induced cataractogenesis. Recently we have reported an inverse dose-rate effect, as well as the low-dose response, of DNA damage and repair in lens epithelial cells (LECs). Here, we present further initial findings from two mutated strains (Ercc2+/- and Ptch1+/-) of mice, both reportedly susceptible to radiation-induced cataract, and their DNA damage and repair response to low-dose and low-dose-rate gamma rays. Our results support the hypothesis that the lens epithelium responds differently to radiation than other tissues, with reported radiation susceptibility to DNA damage not necessarily translating to the LECs. Genetic predisposition and strain(s) of mice have a significant role in radiation-induced cataract susceptibility. ©2022 by Radiation Research Society. All rights of reproduction in any form reserved.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85123324364&doi=10.1667%2fRADE-20-00264.1&partnerID=40&md5=19e9404659533b35fbf0e5affad92f7d
DOI10.1667/RADE-20-00264.1
Citation KeyBarnard202236