Colonic inflammation accelerates the progression of liver disease: A protective role of dipotassium glycyrrhizate

TitoloColonic inflammation accelerates the progression of liver disease: A protective role of dipotassium glycyrrhizate
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2021
AutoriFiaschini, Noemi, Negroni Anna, Palone Francesca, Vitali Roberta, Colantoni Eleonora, Laudadio Ilaria, Mancuso Mariateresa, Cucchiara Salvatore, and Stronati Laura
RivistaDigestive and Liver Disease
Data di pubblicazioneJan-12-2021
ISSN15908658
Astratto

Background: The incidence of non-alcoholic fatty liver disease (NAFLD) and its more severe and progressive form, non-alcoholic steatohepatitis (NASH) is increasing worldwide. Gut inflammation seems to concur to the pathogenesis of NASH. No drugs are currently approved for NASH treatment. Aims: To investigate if inflamed gut directly contributes to the progression of NASH through gut epithelial and vascular barrier impairment and to evaluate the efficacy of dipotassium glycyrrhizate (DPG) to improve the liver disease. Methods: A NASH model was set up by feeding mice, for 8 and 13 weeks, with high fat diet with high fructose and glucose (HFD-FG) supplemented periodically with dextran sulfate sodium (DSS) in drinking water. A group was also treated with DPG by gavage. Histological, immunohistochemical and molecular analysis were performed. Results: DSS-induced colitis increased steatosis, inflammatory (IL-6, TNFα, NLRP3, MCP-1) as well as fibrotic (TGF-β, α-SMA) mediator expression in HFD-FG mice. Beneficial effect of DPG was associated with restoration of intestinal epithelial and vascular barriers, evaluated respectively by ZO-1 and PV-1 expression, that are known to limit bacterial translocation. Conclusion: Colonic inflammation strongly contributes to the progression of NASH, likely by favouring bacterial translocation. DPG treatment could represent a novel strategy to reduce liver injury. © 2021

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URLhttps://linkinghub.elsevier.com/retrieve/pii/S1590865821008549https://api.elsevier.com/content/article/PII:S1590865821008549?httpAccept=text/xmlhttps://api.elsevier.com/content/article/PII:S1590865821008549?httpAccept=text/plainhttps://dul.usage.elsevier.
DOI10.1016/j.dld.2021.11.015
Titolo breveDigestive and Liver Disease