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Effects of sub-chronic oral exposure to pyrogenic synthetic amorphous silica (NM-203) in male and female Sprague-Dawley rats: focus on reproductive systems

TitoloEffects of sub-chronic oral exposure to pyrogenic synthetic amorphous silica (NM-203) in male and female Sprague-Dawley rats: focus on reproductive systems
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2021
AutoriTassinari, R., Cordelli Eugenia, Eleuteri Patrizia, Villani P., Pacchierotti Francesca, Narciso L., Tait S., Valeri M., Martinelli A., Di Felice G., Butteroni C., Barletta B., Corinti S., Lori G., and Maranghi F.
RivistaReproductive Toxicology
Volume105
Paginazione17-24
ISSN08906238
Abstract

Synthetic amorphous silica (SAS) consists of agglomerates and aggregates of primary particles in the nanorange (<100 nm) and it is the E551 authorized food additive. The potential risks for human health associated to dietary exposure to SAS are not completely assessed; in particular, data on male and female reproductive systems are lacking. A 90-day oral toxicity study with pyrogenic SAS nanomaterial NM-203 was carried out on the basis of the OECD test guideline 408 in the frame of the NANoREG project. Adult Sprague-Dawley rats of both sexes were orally treated for 90 days with 0, 2, 5, 10, 20 and 50 mg SAS/kg bw per day. Dose levels were selected to be as close as possible to the expected human exposure to food additive E551. The present paper provides specific information on potential effects on male and female reproductive systems, through the evaluation of serum biomarkers, sperm count, histopathological analysis of testis, epididymis, ovary and uterus and real-time PCR on uterus; potential genotoxic alterations were evaluated by comet assay on testis, sperm and ovary. NM-203 did not induce histophatological and genotoxic effects in male reproductive system. In female rats, ovary is not target of NM-203 and only tissue-specific effects on uterus were recorded up to 10 mg/kg bw per day. To our best knowledge, this is the first study providing data on male and female reproductive systems after long-term, repeated oral exposure at dose levels close to dietary human exposure, which identifies a limited concern only for female reproductive health. © 2021 Elsevier Inc.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85112434940&doi=10.1016%2fj.reprotox.2021.08.001&partnerID=40&md5=e8084ad2e25bb46077a49d31d0ad7d04
DOI10.1016/j.reprotox.2021.08.001
Citation KeyTassinari202117