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mRNA expression of somatostatin eeceptors (1-5) in MCF7 and MDA-MB231 breast cancer cells

TitolomRNA expression of somatostatin eeceptors (1-5) in MCF7 and MDA-MB231 breast cancer cells
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2021
AutoriMahmoud, A., Mancuso Mariateresa, Tanno Barbara, Bakar M.Z.A., Hamzah H., and Noor M.H.M.
RivistaInternational Journal of Current Research and Review
Volume13
Paginazione9-13
ISSN22312196
Abstract

Background: Breast cancer is one of the most common types of cancer and heterogeneous disease. Somatostatin receptors (SSTRs) are expressed in normal and tumour tissues including breast cancer cells. Objective: The aim of this study to evaluate the expression of SSTRs subtypes 1 - 5 in MCF7 and MDA-MB231 human breast cancer cell lines and compare the levels between two cells. Methods: The detection of mRNA expression levels of SSTRs in MCF7 and MDA-MB231 was performed using quantitative- polymerase chain reaction (qPCR). Results: SSTR1, 2, 3 and 4 mRNA levels were significantly higher in MDA-MB-231 about MCF-7. The expression of SSTR 4 mRNA was highest in MDA-MB231 and MCF-7 cell lines, however, SSTR3 mRNA was least expressed in both cell lines. Conclusion: SSTRs subtypes (1 - 5) were expressed in both MDA-MB231 and MCF7 cells. However, the levels of expression differ between both cell lines. © IJCRR.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85103121446&doi=10.31782%2fIJCRR.2021.13601&partnerID=40&md5=c453c82a12c2e0f5c3dacb7a7621efba
DOI10.31782/IJCRR.2021.13601
Citation KeyMahmoud20219