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Human papillomavirus vaccines in plants

TitoloHuman papillomavirus vaccines in plants
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2010
AutoriGiorgi, C., Franconi Rosella, and Rybicki E.P.
RivistaExpert Review of Vaccines
Volume9
Paginazione913-924
ISSN14760584
Parole chiaveantigen expression, biosynthesis, Biotechnology, capsid protein, Chenopodium quinoa, clinical trial, Electron microscopy, Female, Gene expression, Genetically Modified, genetics, human, Human papillomavirus type 11, Human papillomavirus type 16, Humans, immunogenicity, insect cell, metabolism, multicenter study, Nicotiana benthamiana, nonhuman, oncoprotein, Papillomavirus Vaccines, Pharmaceutical, pharmaceutics, Plants, priority journal, procedures, prophylaxis, protein E7, recombinant vaccine, review, Rhizobium radiobacter, Synthetic, Technology, transgenic plant, uterine cervix carcinoma, vaccine production, Vaccines, virus like agent, Wart virus vaccine, yeast cell
Abstract

Human papillomaviruses are the etiological agents of cervical cancer, one of the two most prevalent cancers in women in developing countries. Currently available prophylactic vaccines are based on the L1 major capsid protein, which forms virus-like particles when expressed in yeast and insect cell lines. Despite their recognized efficacy, there are significant shortcomings: the vaccines are expensive, include only two oncogenic virus types, are delivered via intramuscular injection and require a cold chain. Plant expression systems may provide ways of overcoming some of these problems, in particular the expense. In this article, we report recent promising advances in the production of prophylactic and therapeutic vaccines against human papillomavirus by expression of the relevant antigens in plants, and discuss future prospects for the use of such vaccines. © 2010 Expert Reviews Ltd.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77955255365&doi=10.1586%2ferv.10.84&partnerID=40&md5=1ab6e1ed92abf49153cb77ea599ace42
DOI10.1586/erv.10.84
Citation KeyGiorgi2010913