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Increase in mortality for motor neuron disease in Italy, 1980-1999 [Incremento della mortalità per malattia del motoneurone in Italia negli anni 1980-1999.]

TitoloIncrease in mortality for motor neuron disease in Italy, 1980-1999 [Incremento della mortalità per malattia del motoneurone in Italia negli anni 1980-1999.]
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2006
AutoriAltavista, P., Belli S., Binazzi A., Comba P., Mastrantonio Marina, Uccelli Raffaella, and Vanacore N.
RivistaEpidemiologia e prevenzione.
Volume30
Paginazione108-113
ISSN11209763
Parole chiaveadult, aged, article, Catchment Area (Health), death certificate, Death Certificates, Female, human, Humans, Incidence, Italy, male, Middle Aged, Mortality, Motor Neuron Disease, register, Registries, residential care
Abstract

OBJECTIVE: To describe the mortality rates for motor neuron disease (MND) in Italy both at national level and at three large geographical sub-areas (Northern, Central, Southern Italy). DESIGN: Deaths for MND are coded accordingly to ICD (IX revision) with 335.2 code. Mortality for MND is analysed for the period 1980-99. Mortality rates are age-standardized on the structure of the 1991 Italian population. Mortality data are derived from the National Institute for Statistics (ISTAT) and are made available by the Epidemiological Database of the Italian National Agency for New Technologies, Energy and the Environment (ENEA). MAIN OUTCOME MEASURES: Age adjusted mortality rates for MND are calculated for 5-year periods (1980-84, 1985-89, 1990-94, 1995-99) at both national level and three geographical sub-areas (north, center and south); sex and age specific mortality rates are also reported for two decades (1980-89 and 1990-99). RESULTS: During 1980-99 the annual age-standardized mortality rate in Italy was 1.35 x 100000 in males and 1.10 (x 100000) in females. In the period 1995-99 the mortality rates increased by 39.3% in males and 78.2% in females at national level when compared to 1980-84 rates (1.56 vs 1.12 deaths per 100000 for males and 1.39 vs 0.78 per 100000 for females in 1980-84 and 1995-99, respectively). In the three large geographical sub-areas such increases were 37.6%, 29.7% and 57% in males and 73%, 63.1% and 114.3% in females, respectively. CONCLUSION: The increase reported in this study is probably due to a mix of different factors as population ageing (age-specific rates reach a peak in the age class 70-74 years), better accuracy of death certificates, adoption of new clinical criteria and at last a wide spread of environmental risk factors (metals, solvents, pesticides, electromagnetic fields) and modification of life style (smoking, diet, professional sport).

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33749187797&partnerID=40&md5=f5f90adfd217c89e6237cfb659133775
Citation KeyAltavista2006108