| Titolo | Nanopore test circuit for single-strand DNA sequencing |
|---|---|
| Tipo di pubblicazione | Presentazione a Congresso |
| Anno di Pubblicazione | 2012 |
| Autori | Palego, C., Hwang J.C.M., Merla Caterina, Apollonio F., and Liberti M. |
| Conference Name | 2012 IEEE 12th Topical Meeting on Silicon Monolithic Integrated Circuits in RF Systems, SiRF 2012 - Digest of Papers |
| Parole chiave | Bioelectric phenomena, DNA, DNA sequences, DNA Sequencing, DNA strands, Electron beams, Genomics, Graphite electrodes, Individual sections, Lipid bilayer membranes, Lipid Bilayers, Liposomes, Micro-chambers, Microelectrodes, Monolithic integrated circuits, Nano channels, Nanobiosciences, Nanopores, Nanosecond electric pulse, Phospholipids, Pulse measurements, Real time sensing, Repetition rate, Self-aligned, Test circuit |
| Abstract | A nanopore test circuit is proposed for single-strand DNA sequencing, which allows real-time sensing of the electric conductance of individual sections of a DNA strand as it is pulled through the nanopore by an electric current at a controlled speed. The test circuit is based on a planar microchamber with a nanochannel drilled through its multilayer graphene electrode by an electron beam. The nanochannel is self-aligned with a nanopore created in the lipid bilayer membrane of liposomes by nanosecond electric pulses. Simulation shows that by carefully controlling the magnitude, period, and repetition rate of the pulses, the diameter of the nanopore can be optimized for the best speed the DNA is pulled through the nanopore. © 2012 IEEE. |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84858726282&doi=10.1109%2fSiRF.2012.6160154&partnerID=40&md5=1371e16ea984375607951f9ca31f0bf8 |
| DOI | 10.1109/SiRF.2012.6160154 |
| Citation Key | Palego2012101 |
