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Coplanar stripline microchamber for electrical detection of live and dead biological cells

TitoloCoplanar stripline microchamber for electrical detection of live and dead biological cells
Tipo di pubblicazionePresentazione a Congresso
Anno di Pubblicazione2013
AutoriNing, Y., Multari C., Luo X., Palego C., Molinero D., Cheng X., Hwang J.C.M., and Merla Caterina
Conference NameEuropean Microwave Week 2013, EuMW 2013 - Conference Proceedings; EuMC 2013: 43rd European Microwave Conference
Parole chiaveBio-impedance, Biological cells, Biosensors, Coplanar striplines, Coplanar waveguides, Electrical detection, Equivalent-circuit model, Fabrication, Fluidic devices, Microchannels, Microfluidic channel, Microfluidics, Microsensors, Microwaves, Quartz, Reflectometry, Sapphire, Silicones, Time and frequency domains
Abstract

An improved microchamber for electrical detection of biological cells was designed, fabricated and tested. The microchamber was formed between a gold coplanar stripline fabricated on a sapphire microscope slide and a single microfluidic channel fabricated in a polydimethylsiloxane cover. Compared with the previous design of a coplanar waveguide on a quartz slide with multiple microfluidic channels, the present microchamber was more sensitive, compact, rugged, and transparent. Tests on Jurkat cells in both time and frequency domains demonstrated single-cell sensing potential, as well as discrimination of live vs. dead cells. The test results could be explained by a simple equivalent-circuit model, which efficiently de-embedded the intrinsic cell properties from solution and electrode effects. © 2013 European Microwave Association.

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84893473616&partnerID=40&md5=aab30438c41c0ae932215f17d5cb1633
Citation KeyNing2013475