Titolo | Effects of Dichlobenil on Ultrastructural Morphology and Cell Replication in the Mouse Olfactory Mucosa |
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Tipo di pubblicazione | Articolo su Rivista peer-reviewed |
Anno di Pubblicazione | 1997 |
Autori | Mancuso, Mariateresa, Giovanetti Anna, and Brittebo E.B. |
Rivista | Toxicologic Pathology |
Volume | 25 |
Paginazione | 186-194 |
ISSN | 01926233 |
Parole chiave | animal experiment, animal tissue, Animalia, Animals, article, autoradiography, Benzamides, Cell Division, controlled study, dichlobenil, DNA synthesis, Female, Follow-Up Studies, herbicide, Herbicides, histopathology, Inbred C57BL, lamina propria, Mice, Microscopy, mouse, Necrosis, neuroepithelium, Nitriles, nonhuman, olfactory epithelium, Olfactory Mucosa, priority journal, tissue necrosis, Transmission electron microscopy, Ultrastructure, Vacuoles, Vehicles |
Abstract | The herbicide dichlobenil (2,6-dichlorobenzonitrile) is a tissue-specific toxicant inducing necrosis in the olfactory mucosa. Transmission electron microscopy showed vacuolations (1 hr) and necrosis (4 hr) in the Bowman's glands following intraperitoneal injection of dichlobenil (25 mg/kg) in C57B1 mice, whereas no lesions were noted in the olfactory neuroepithelium at these timepoints. Twenty-four hr following injection (25 mg/kg), most of the lamina propria and the olfactory epithelium were severely damaged; the basal lamina, nerves, and blood vessels in the lamina propria, however, remained intact. Following a lower dose (12 mg/kg), the lesions were not as pronounced. The effects of dichlobenil (6, 12, and 25 mg/kg) on cell replication in the olfactory mucosa, as determined by incorporation of 3H-thymidine 3 days later, were more pronounced in the lamina propria than in the neuroepithelium and occurred at a lower dose in the lamina propria than in the neuroepithelium. Together these studies support the previous proposal that dichlobenil induces a primary damage in the Bowman's glands. © 1997, Sage Publications. All rights reserved. |
Note | cited By 16 |
URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030936838&doi=10.1177%2f019262339702500208&partnerID=40&md5=bc14901449cbf8ce566286a6886677f5 |
DOI | 10.1177/019262339702500208 |
Citation Key | Mancuso1997186 |