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Effects of Dichlobenil on Ultrastructural Morphology and Cell Replication in the Mouse Olfactory Mucosa

TitoloEffects of Dichlobenil on Ultrastructural Morphology and Cell Replication in the Mouse Olfactory Mucosa
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione1997
AutoriMancuso, Mariateresa, Giovanetti Anna, and Brittebo E.B.
RivistaToxicologic Pathology
Volume25
Paginazione186-194
ISSN01926233
Parole chiaveanimal experiment, animal tissue, Animalia, Animals, article, autoradiography, Benzamides, Cell Division, controlled study, dichlobenil, DNA synthesis, Female, Follow-Up Studies, herbicide, Herbicides, histopathology, Inbred C57BL, lamina propria, Mice, Microscopy, mouse, Necrosis, neuroepithelium, Nitriles, nonhuman, olfactory epithelium, Olfactory Mucosa, priority journal, tissue necrosis, Transmission electron microscopy, Ultrastructure, Vacuoles, Vehicles
Abstract

The herbicide dichlobenil (2,6-dichlorobenzonitrile) is a tissue-specific toxicant inducing necrosis in the olfactory mucosa. Transmission electron microscopy showed vacuolations (1 hr) and necrosis (4 hr) in the Bowman's glands following intraperitoneal injection of dichlobenil (25 mg/kg) in C57B1 mice, whereas no lesions were noted in the olfactory neuroepithelium at these timepoints. Twenty-four hr following injection (25 mg/kg), most of the lamina propria and the olfactory epithelium were severely damaged; the basal lamina, nerves, and blood vessels in the lamina propria, however, remained intact. Following a lower dose (12 mg/kg), the lesions were not as pronounced. The effects of dichlobenil (6, 12, and 25 mg/kg) on cell replication in the olfactory mucosa, as determined by incorporation of 3H-thymidine 3 days later, were more pronounced in the lamina propria than in the neuroepithelium and occurred at a lower dose in the lamina propria than in the neuroepithelium. Together these studies support the previous proposal that dichlobenil induces a primary damage in the Bowman's glands. © 1997, Sage Publications. All rights reserved.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0030936838&doi=10.1177%2f019262339702500208&partnerID=40&md5=bc14901449cbf8ce566286a6886677f5
DOI10.1177/019262339702500208
Citation KeyMancuso1997186