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Harnessing mosquito-Wolbachia symbiosis for vector and disease control

TitoloHarnessing mosquito-Wolbachia symbiosis for vector and disease control
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2014
AutoriBourtzis, K., Dobson S.L., Xi Z., Rasgon J.L., Calvitti Maurizio, Moreira L.A., Bossin H.C., Moretti Riccardo, Baton L.A., Hughes G.L., Mavingui P., and Gilles J.R.L.
RivistaActa Tropica
Parole chiaveAedes, Aedes albopictus, aedes polynesiensis, Animals, article, bacterial infection, bacterial strain, bacterium identification, Biological, biological pest control, control strategy, Culex pipiens, Culex quinquefasciatus, Disease control, disease treatment, disease vector, Genetic variability, Hexapoda, infection control, insect control, Insect Vectors, insecticide, intermethod comparison, malaria, mosquito, Mosquito Control, mosquitoes, nonhuman, organismal interaction, pathogen, pest control, phylogeography, Plasmodium sp., Protozoa, radiation sterilization, species distribution, species diversity, Sterile Insect Technique, symbiosis, Toxicity, Vector Control, virus, Wolbachia

Mosquito species, members of the genera Aedes, Anopheles and Culex, are the major vectors of human pathogens including protozoa (Plasmodium sp.), filariae and of a variety of viruses (causing dengue, chikungunya, yellow fever, West Nile). There is lack of efficient methods and tools to treat many of the diseases caused by these major human pathogens, since no efficient vaccines or drugs are available; even in malaria where insecticide use and drug therapies have reduced incidence, 219 million cases still occurred in 2010. Therefore efforts are currently focused on the control of vector populations. Insecticides alone are insufficient to control mosquito populations since reduced susceptibility and even resistance is being observed more and more frequently. There is also increased concern about the toxic effects of insecticides on non-target (even beneficial) insect populations, on humans and the environment. During recent years, the role of symbionts in the biology, ecology and evolution of insect species has been well-documented and has led to suggestions that they could potentially be used as tools to control pests and therefore diseases. Wolbachia is perhaps the most renowned insect symbiont, mainly due to its ability to manipulate insect reproduction and to interfere with major human pathogens thus providing new avenues for pest control. We herein present recent achievements in the field of mosquito Wolbachia symbiosis with an emphasis on Aedes albopictus. We also discuss how Wolbachia symbiosis can be harnessed for vector control as well as the potential to combine the sterile insect technique and Wolbachia-based approaches for the enhancement of population suppression programs. © 2013 International Atomic Energy Agency 2013.


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Citation KeyBourtzis2014