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Glucocorticoids: Inflammation and immunity

TitoloGlucocorticoids: Inflammation and immunity
Tipo di pubblicazioneMonografia
Anno di Pubblicazione2016
AutoriPetrillo, Maria Grazia, Bortner Carl D., and Cidlowski John A.
Series TitleThe Hypothalamic-Pituitary-Adrenal Axis in Health and Disease: Cushing's Syndrome and Beyond
Number of Pages43 – 63
EditoreSpringer International Publishing
Abstract

Glucocorticoids are universally prescribed as the drug of choice for the treatment of inflammatory and autoimmune disorders. These stress hormones act through their cognate glucocorticoid receptor to regulate transcription of various target genes. The mechanisms of glucocorticoid action are often cell type dependent and involve the regulation of thousands of genes. Glucocorticoids have a tremendous impact on the immune system during inflammation including effects on the plasticity, survival, and function of immune cells. This chapter highlights the dynamic effects of glucocorticoids in regards to both physiological and pathological conditions during inflammation. We address issues involving classical and alternative mechanisms of glucocorticoid inhibition, the effect on innate and adaptive immunity, glucocorticoid tissue-specific actions, and their role in target immune cells. © Springer International Publishing Switzerland 2017.

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85029091327&doi=10.1007%2f978-3-319-45950-9_3&partnerID=40&md5=24016e932623b05c4ffa684f059e7df3
DOI10.1007/978-3-319-45950-9_3
Citation KeyPetrillo201643