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Antiproliferative activity of three lichen species belonging to the genus Peltigera

TitoloAntiproliferative activity of three lichen species belonging to the genus Peltigera
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2014
AutoriMunzi, S., Triggiani Doriana, Ceccarelli D., Climati E., Tiezzi A., Pisani T., Paoli L., and Loppi S.
RivistaPlant Biosystems
Volume148
Paginazione83-87
ISSN11263504
Parole chiaveMurinae, Peltigera, Peltigera canina, Peltigera elisabethae, Peltigera praetextata
Abstract

The results of antiproliferative activity against murine myeloma cells (line P3X63-Ag8.653) of water, ethanol, and methanol crude extracts of three lichen species belonging to the genus Peltigera (P. canina, P. elisabethae, and P. praetextata) are reported. Cell proliferation was evaluated by means of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test, which is commonly used to assess the activity of living cells through mitochondrial dehydrogenases. The results showed that water extracts were the most effective in reducing cell proliferation; however, 40 μl of all Peltigera extracts, irrespective of water, ethanol, or methanol, induced a consistent reduction in cell proliferation. It is suggested that this important biological activity is due to antioxidant properties, possibly linked with phenolic compounds. A possible role of quaternary ammonium compounds is also discussed. © 2014 © 2013 Societá Botanica Italiana.

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cited By 5

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84898058115&doi=10.1080%2f11263504.2012.760015&partnerID=40&md5=1148ed4a55472b3fa0ee6e18910118cb
DOI10.1080/11263504.2012.760015
Citation KeyMunzi201483