Technology innovation is critical for an effective, long-term global response to climate change. International collaboration is a pillar for building a suitable environment that can enable and sustain the growth of both mitigation and adaptation technologies. In this article, the Italian experience in the participation at “Mission Innovation”, an international collaboration initiative instituted at COP21 to foster research in energy technology, is described. A set of recommendations to policymakers for the setting up of a successful international innovation initiative is proposed. © 2023, The Author(s), under exclusive licence to Springer Nature Japan KK, part of Springer Nature.

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