Antimicrobial activity of catechol functionalized-chitosan versus Staphylococcus epidermidis

TitleAntimicrobial activity of catechol functionalized-chitosan versus Staphylococcus epidermidis
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2018
AuthorsAmato, A., Migneco L.M., Martinelli A., Pietrelli L., Piozzi A., and Francolini I.
JournalCarbohydrate Polymers
Volume179
Pagination273-281
ISSN01448617
Keywords3, 4-dihydroxyphenylpropionic acid, Adhesive properties, Anti-Infective Agents, Anti-microbial activity, antiinfective agent, Antioxidant properties, Bioadhesive polymers, biofilm, Biofilms, caffeic acid derivative, Caffeic Acids, catechol derivative, Catechols, chemistry, Chitin, Chitosan, drug effect, Hydrocaffeic acid, microbial sensitivity test, Microbial Sensitivity Tests, Microorganisms, minimum inhibitory concentration, Molluscs, Phenols, physiology, Polymers, Proteins, Staphylococcus epidermidis, Wound dressings, wound healing
Abstract

Protein mussel-inspired adhesive polymers, characterized by the presence of catechol groups, possess superior muco-adhesive properties and have great potentiality in wound healing. Suitable materials for wound dressing should properly combine muco-adhesiveness and antimicrobial activity. In this work, catechol-functionalized chitosan was obtained by reaction with hydrocaffeic acid (HCAF), in order to investigate how catechol introduction at different content could affect the intrinsic antimicrobial activity of the polymer itself. Unexpectedly, an enhancement of chitosan antimicrobial activity was observed after catechol functionalization, with a fourfold reduction in the polymer minimum inhibitory concentration versus Staphylococcus epidermidis. Additionally, a commercial wound dressing coated with one of the synthesized CS-HCAF derivatives showed a significant reduction in the adhesion of S. epidermidis compared to the uncoated dressing (3-log reduction). The CS-HCAF derivatives also showed an interesting antioxidant property (EC50 ranging from 20 to 60 μg/mL), which further confirms the potentiality of these materials as wound dressings. © 2017 Elsevier Ltd

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85030559538&doi=10.1016%2fj.carbpol.2017.09.073&partnerID=40&md5=030e7f9419fdca68b4959152ca3e38b9
DOI10.1016/j.carbpol.2017.09.073