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DNA damages and offspring quality in sea urchin Paracentrotus lividus sperms exposed to ZnO nanoparticles

TitleDNA damages and offspring quality in sea urchin Paracentrotus lividus sperms exposed to ZnO nanoparticles
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2019
AuthorsOliviero, M., Schiavo S., Dumontet S., and Manzo Sonia
JournalScience of the Total Environment
Volume651
Pagination756-765
ISSN00489697
Keywordsadult, article, assay, coastal waters, Comet Assay, Comet assays, concentration (parameters), controlled study, Damage detection, Data integration, DNA, DNA damage, EC50, echinoderm, Echinoidea, Female, fertilization, Genotoxicities, genotoxicity, II-VI semiconductors, larva, male, Mammals, Marine biology, Marine coastal water, Marine contamination, Marine pollution, Morphological alteration, Nanomaterial, nanoparticle, Nanoparticle (NPs), Nanoparticles, Nanostructured materials, nonhuman, Paracentrotus lividus, particle size, photon correlation spectroscopy, physical chemistry, Positive correlations, priority journal, progeny, scoring system, sperm, spermatozoon, Spermiotoxicity, Zinc, Zinc oxide, zinc oxide nanoparticle, ZnO nanoparticles
Abstract

The recent advances in nanotechnology lead to a potential increase of the release of nanoparticles (NPs) into marine environment through different routes, with possible toxic effects upon the living part of this ecosystem. One of the ways of NPs marine contamination gaining today increasing concern stems from the widespread use cosmetics containing ZnO NPs as UV-filter. Although the possible adverse effects on marine organisms have been already ascertained, the information about the possible genotoxicity of ZnO NPs is still scant. In this work the spermiotoxicity of ZnO particles of different sizes (ZnO Bulk > 200 nm, ZnO NPs 100 nm and ZnO NPs 14 nm) was assessed, using Paracentrotus lividus spermatozoa, by evaluating the DNA damage of the exposed sperm, fertilization capability and DNA damage transmission to progeny. Our results showed that ZnO NPs induced DNA damages in spermatozoa after 30 min of exposure. While the sperm fertilization capability was not affected, morphological alterations (skeletal alterations) in offspring were observed and a positive correlation between sperm DNA damage and offspring quality was reported. This study underlines that a possible spermiotoxic action of ZnO NPs at concentration close to those reported in marine coastal water could occur. © 2018

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85053798064&doi=10.1016%2fj.scitotenv.2018.09.243&partnerID=40&md5=95af1044a23c5ecf36df31e2653126cd
DOI10.1016/j.scitotenv.2018.09.243
Citation KeyOliviero2019756