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Quantitative assessment of dielectric parameters for membrane lipid bi-layers from rf permittivity measurements

TitleQuantitative assessment of dielectric parameters for membrane lipid bi-layers from rf permittivity measurements
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2009
AuthorsMerla, Caterina, Liberti M., Apollonio F., and d'Inzeo G.
JournalBioelectromagnetics
Volume30
Pagination286-298
ISSN01978462
Keywordsarticle, Biological, biological model, cell membrane, dielectric constant, Electric conductivity, electric field, electric model, experimental study, lipid bilayer, Lipid Bilayers, liposome, membrane permeability, microdosimetry, Models, priority journal, quantitative analysis, Radio Waves, radiofrequency radiation, radiometry, Temperature, Theoretical, theoretical model, theoretical study, Unilamellar Liposomes
Abstract

{In this article, we propose and validate theoretical and experimental methods to quantitatively assess the Debye dielectric model of membrane lipid bi-layers. This consists of two steps: permittivity measurements of biological solutions (liposomes), and estimation of the model parameters by inverse application of the Effective Medium Theory. The measurements are conducted in the frequency domain between 100 MHz and 2 GHz using a modified coaxial connector, at the temperatures of 27 and 30 °C. Estimations have been performed using a three-layered model based on the Maxwell-Wagner formulation. Debye parameters (mean value ± standard error) found from fitting experimental data are: εs- 11.69 ±0.09, ε∞ = 4.00 ±0.07

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-66149142275&doi=10.1002%2fbem.20476&partnerID=40&md5=e9bb8e0f030dc3278dc5330adac81e00
DOI10.1002/bem.20476
Citation KeyMerla2009286