| Title | Plasma high mobility group box 1 protein reflects fibrosis in pediatric nonalcoholic fatty liver disease |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2014 |
| Authors | Alisi, A., Nobili V., Ceccarelli S., Panera N., De Stefanis C., De Vito R., Vitali Roberta, Bedogni G., Balsano C., Cucchiara S., and Stronati L. |
| Journal | Expert Review of Molecular Diagnostics |
| Volume | 14 |
| Pagination | 763-771 |
| ISSN | 14737159 |
| Keywords | adolescent, alanine aminotransferase, alanine aminotransferase blood level, aspartate aminotransferase, aspartate aminotransferase blood level, Biopsy, blood, case control study, Case-Control Studies, Chemokine CCL2, Child, childhood disease, complication, controlled study, Cross-Sectional Studies, cross-sectional study, Female, high mobility group B1 protein, HMGB1 Protein, human, human tissue, Humans, inflammation, liver biopsy, liver cirrhosis, liver fibrosis, liver histology, liver injury, major clinical study, male, monocyte chemotactic protein 1, Non-alcoholic Fatty Liver Disease, nonalcoholic fatty liver, Pathology, Preschool, preschool child, protein blood level, review, transforming growth factor beta |
| Abstract | Non-alcoholic fatty liver disease (NAFLD) affects 3-12% of the general pediatric population. HMGB1 protein is presently considered a potent inflammatory mediator in several liver diseases, even if its role in NAFLD is still unknown in clinical studies. Here we investigated the relationships between circulating HMGB1, TGF-β and MCP-1 and liver damage in pediatric NAFLD. HMGB1, TGF-β and MCP-1 plasma levels were measured in 110 obese children with biopsy-proven NAFLD and 40 age-matched obese controls. HMGB1, TGF-β and MCP-1, ALT, AST and cholesterol plasma levels were significantly higher in NAFLD than in control children. A significant association between increased levels of HMGB1, TGF-β and MCP-1 and high degrees of fibrosis was found. In this study, we showed for the first time that circulating levels of HMGB1 were raised in children with NAFLD and strongly correlated with fibrosis and systemic inflammation. © 2014 Informa UK, Ltd. |
| Notes | cited By 4 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903216539&doi=10.1586%2f14737159.2014.928205&partnerID=40&md5=195d532a165e0a4e624beddcce2219d0 |
| DOI | 10.1586/14737159.2014.928205 |
| Citation Key | Alisi2014763 |
