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Embryotoxicity and spermiotoxicity of nanosized ZnO for Mediterranean sea urchin Paracentrotus lividus

TitleEmbryotoxicity and spermiotoxicity of nanosized ZnO for Mediterranean sea urchin Paracentrotus lividus
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2013
AuthorsManzo, Sonia, Miglietta M.L., Rametta G., Buono S., and Di Francia G.
JournalJournal of Hazardous Materials
Keywordsabnormality, Animals, article, echinoderm, Echinoidea, ecotoxicology, electron, Embryo, embryo development, Embryonic Development, embryotoxicity, Female, fertilization, larva, larval development, male, Mammals, Mediterranean Sea, Metal nanoparticles, Microscopy, nanotechnology, nonhuman, Nonmammalian, Paracentrotus, Paracentrotus lividus, pollution effect, pollution exposure, progeny, Scanning, Sea urchin, sea water, Seawater, Shellfish, skeleton, skeleton malformation, sperm, spermatophore, Spermatozoa, Spermiotoxicity, Toxicity, Zinc, zinc chloride, zinc ion, Zinc oxide, ZnO nanoparticles

The effect of nano ZnO (nZnO) upon the fertilization and early development of embryos of the Mediterranean sea urchin Paracentrotus lividus is reported herein for the first time. Zn ion (ZnCl2) and bulk ZnO (bZnO) toxicity were assessed for comparison. The embryotoxicity tests showed a 100% effect already at 1μM of nZnO (expressed as [Zn]) while bZnO and ZnCl2 showed EC50s of 0.98 [0.88-1.19]μM [Zn] and 2.02 [1.97-2.09]μM [Zn], respectively. Noteworthy, the frequency of developmental defects for the three compounds was dissimilar and a specific trend for larval skeletal abnormality produced by nZnO was observed. The sperm fertilization capability was only slightly affected by the tested chemicals while the effects were dramatic on the offspring quality of sperms exposed to ZnO compounds resulting in an early block of the regular larval development. ZnO toxicity seems related not only to Zinc ions but also to some surface interactions of particle/aggregates with target organisms and/or with the seawater. © 2013 Elsevier B.V.


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Citation KeyManzo20131