Antioxidant hydroxytyrosol-based polyacrylate with antimicrobial and antiadhesive activity versus Staphylococcus epidermidis

TitleAntioxidant hydroxytyrosol-based polyacrylate with antimicrobial and antiadhesive activity versus Staphylococcus epidermidis
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2016
AuthorsCrisante, F., Taresco V., Donelli G., Vuotto C., Martinelli A., D’Ilario L., Pietrelli L., Francolini I., and Piozzi A.
JournalAdvances in Experimental Medicine and Biology
Volume901
Pagination25-36
ISSN00652598
Keywords2 (3, 2 (3', 3, 4 hydroxyphenyl)ethyl acrylic acid, 4' dihydroxyphenyl)ethanol, 4-dihydroxyphenylethanol, analogs and derivatives, Anti-Bacterial Agents, antiadhesive activity, antiinfective agent, antimicrobial activity, Antioxidant, Antioxidants, article, Bacterial Adhesion, bacterial strain, bacterium adherence, biofilm, Biofilms, chemistry, chronic wound, controlled study, development and aging, DPPH radical scavenging assay, drug activity, drug determination, drug effects, drug synthesis, EC50, growth, Hydroxytyrosol, microbial sensitivity test, Microbial Sensitivity Tests, nanoparticle, nonhuman, phenethyl alcohol, Phenylethyl Alcohol, physiology, polyacrylic acid, priority journal, Staphylococcus epidermidis, tyrosol, unclassified drug
Abstract

The accumulation of reactive oxygen species (ROS) in microbial biofilms has been recently recognized to play a role in promoting antibiotic resistance in biofilm-growing bacteria. ROS are also over-produced when a medical device is implanted and they can promote device susceptibility to infection or aseptic loosening. High levels of ROS seem also to be responsible for the establishment of chronic wounds. In this study, a novel antioxidant polyacrylate was synthesized and investigated in terms of antimicrobial and antibiofilm activity. The polymer possesses in side-chain hydroxytyrosol (HTy), that is a polyphenolic compound extracted from olive oil wastewaters. The obtained 60 nm in size polymer nanoparticles showed good scavenging and antibacterial activity versus a strain of Staphylococcus epidermidis. Microbial adherence assays evidenced that the hydroxytyrosol-containing polymer was able to significantly reduce bacterial adhesion compared to the control. These findings open novel perspective for a successful use of this antioxidant polymer for the prevention or treatment of biofilm-based infections as those related to medical devices or chronic wounds. © Springer International Publishing Switzerland 2015.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84990246172&doi=10.1007%2f5584_2015_5013&partnerID=40&md5=8acf593e2fe6deb1910acbcb51005abf
DOI10.1007/5584_2015_5013