| Title | Use of hematopoetic cytokines to accelerate the recovery of the immune system in irradiated mice |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 1997 |
| Authors | Frasca, D., Guidi F., Arbitrio M., Pioli Claudio, Leter Giorgio, Spanò M., and Doria G. |
| Journal | Experimental Hematology |
| Volume | 25 |
| Pagination | 1167-1171 |
| ISSN | 0301472X |
| Keywords | animal, animal cell, animal experiment, animal model, animal tissue, Animals, article, B lymphocyte, B-Lymphocytes, bone marrow, bone marrow cell, Bone Marrow Cells, C57BL mouse, CD4+ T lymphocyte, CD4-Positive T-Lymphocytes, CD8+ T lymphocyte, CD8-Positive T-Lymphocytes, Cell cycle, cell differentiation, cell growth, concanavalin a, controlled study, cytokine, Cytokines, Dose-Response Relationship, drug effect, Flow cytometry, hematopoiesis, human, Humans, immune response, immunology, Inbred C57BL, interleukin 11, interleukin 3, Interleukin-11, Interleukin-3, lymphocyte, male, Mice, mitosis, mitosis index, Mitotic Index, mouse, nonhuman, priority journal, Radiation, radiation dose, Radiation exposure, radiation injury, radiation response, recombinant interleukin 11, recombinant interleukin 3, recombinant protein, Recombinant Proteins, Spleen, subcutaneous drug administration, T lymphocyte, T-Lymphocytes, thymus, Thymus Gland, whole body radiation, Whole-Body Irradiation, X ray, X-Rays |
| Abstract | In our previous studies aimed at designing appropriate strategies to accelerate recovery of the immune system after irradiation, we found that the hematopoietic cytokine recombinant murine (rmu) interleukin (IL)-3 was able to induce differentiation and growth of thymocytes and splenic T and B lymphocytes in mice exposed to x-rays (200-500 cGy). The recovery, however, was complete at 7 days only after a dose of 200 cGy, whereas 2, 3, and 4 weeks were necessary to achieve full recovery after 300, 400, and 500 cGy, respectively. These studies were extended to investigate the effects of another hematopoietic cytokine, recombinant human (rhu) IL-11, a bone marrow stromal-derived cytokine, administered together with IL-3 to irradiated mice. The synergistic effect of the two cytokines was evident when relatively small doses of rhu IL-11 were injected with an optimal dose of rmu IL-3. |
| Notes | cited By 6 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030611033&partnerID=40&md5=d5a1e5fa04370377615aee1868a37f18 |
| Citation Key | Frasca19971167 |
