A global guidance for application of detailed Life Cycle Assessment (LCA) to FC technologies, processes and systems has been developed within the EU funded FC-HyGuide Consortium. The tool (manual, PCRs, case studies) aims at providing entrepreneurs, consultants and experts with a standardized and ILCD (International Reference Life Cycle Data System) compliant guidance for use in policy context and reliable decision-making support. The main aspects that have been addressed are: (1) data quality assessment; (2) crucial information needed; (3) background and foreground data; (4) FC stack and balance of system; (5) perspectives on technological evolution; (6) protection of property rights; (7) end of life and recycle. Three LCA case studies dealing with different FC technologies, namely Molten Carbonate Fuel Cells (MCFCs), Solid Oxide Fuel Cells (SOFCs), Polymer Electrolyte Membrane Fuel Cells (PEMFCs) were also carried out as a template for the Guidance Manual application.