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Inhibition of intestinal inflammation and fibrosis by Scutellaria Baicalensis georgi and Boswellia serrata in human epithelial cells and fibroblasts

TitoloInhibition of intestinal inflammation and fibrosis by Scutellaria Baicalensis georgi and Boswellia serrata in human epithelial cells and fibroblasts
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2024
AutoriLaudadio, Ilaria, Leter Beatrice, Palone Francesca, Cucchiara Salvatore, Carissimi Claudia, Scafa Noemi, Secci Daniela, Vitali Roberta, and Stronati L.
RivistaImmunity, Inflammation and Disease
Volume12
Type of ArticleArticle
ISSN20504527
Abstract

Objective and Rationale: Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, manifests with chronic intestinal inflammation and frequent sequential fibrosis. Current pharmacological therapies may show harmful side effects and are not useful for prevention or resolution of fibrosis. Thus, the use of alternative therapies is emerging as a novel useful approach. Previous results suggest that Scutellaria baicalensis Georgi (SBG) and Boswellia serrata (BS) display anti-inflammatory properties. The aim of this study was to investigate in intestinal epithelial cells and fibroblasts the anti-inflammatory and anti-fibrotic potential of SBG and BS, alone or in combination. Methods: Human colorectal adenocarcinoma cells (HT29), human intestinal epithelial cells (HIEC6) and human colon fibroblasts (CCD-18Co) were used. Cells were pretreated with SBG and BS and then exposed to pro-inflammatory and pro-fibrotic cytokines. Results: SBG and BS extracts significantly decreased pro-inflammatory cytokine expression and improved epithelial restitution in HT29 and HIEC6 cells. Besides, fibrotic marker expression, including SNAIL, ACTA2, ZNF281, was strongly reduced. Colon myofibroblasts treated with SBG and BS showed a significant decrease of fibrotic markers as well. Conclusions: SBG and BS extracts significantly reduce inflammation and impair fibrosis in intestinal epithelial cells and colon myofibroblasts. No cooperative effect is observed. © 2024 The Author(s). Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.

Note

Cited by: 0; All Open Access, Gold Open Access

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85205775607&doi=10.1002%2fiid3.70036&partnerID=40&md5=46c2c004046f80602b9b24b1aa2afc6a
DOI10.1002/iid3.70036
Citation KeyLaudadio2024
PubMed ID39377749