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Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design

TitoloCombating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2014
AutoriSantoro, Aurelia, Pini Elisa, Scurti Maria, Palmas Giustina, Berendsen Agnes, Brzozowska Anna, Pietruszka Barbara, Szczecinska Anna, Cano Noël, Meunier Nathalie, de Groot C.P.G.M., Feskens Edith, Fairweather-Tait Susan, Salvioli Stefano, Capri Miriam, Brigidi Patrizia, Franceschi Claudio, Fabbri Cristina, Bertarelli Claudia, Izzi Massimo, Mazzocchi Mario, Chardigny Jean Michel, Morio Beatrice, Rossi Daniele, Notarfonso Maurizio, O'Toole Paul W., Cashman Kevin, Carding Simon R., Nicoletti Claudio, Jacobs Dirk, Xipsiti Maria, Fernandez Laura, Wills Josephine, Irz Xavier, Kuosmanen Natalia, Gonos Efstathios S., Voutetakis Konstantinos, Salmon Michael, Toussaint Olivier, Traill Bruce W., Nocella Giuseppe, Caracciolo Barbara, Xu Weili, Ikonen Mikko, Tuure Tuula, Brummer Robert, Kadi Fawzi, Breton Sylvie, Triomphe Marie, Magario Guido, Villani Filippo, Pancrazio Annibale, Teufner Brigitte, Stocker Josef, Echevarría Francisco Javier, Iglesias Jose Ramón, Smrž František, Krejcirova Lucie, Koytsomitropoulou Efthimia, Georgakidis Konstantinos, Yornuk Rezan, Ucar Cihan, Van Ommen Ben, Bouwman Jildau, Collino Sebastiano, Jankovics Clara, Losó Adrienn, de Vos Willem, Fuentes Susana, and Commelin Eric
RivistaMechanisms of Ageing and Development
Volume136-137
Paginazione3 – 13
Type of ArticleArticle
ISSN00476374
Abstract

The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65-79 years of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics and metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and ageing, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food & Drink Industries. © 2013.

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Cited by: 105

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84899939543&doi=10.1016%2fj.mad.2013.12.001&partnerID=40&md5=bba71580ae4365e4989602255aff2153
DOI10.1016/j.mad.2013.12.001
Citation KeySantoro20143
PubMed ID24342354