Sorry, you need to enable JavaScript to visit this website.

Graphene-laden hydrogels: A strategy for thermally triggered drug delivery

TitleGraphene-laden hydrogels: A strategy for thermally triggered drug delivery
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2021
AuthorsMauri, E., Salvati A., Cataldo Antonino, Mozetic P., Basoli F., Abbruzzese F., Trombetta M., Bellucci S., and Rainer A.
JournalMaterials Science and Engineering C
KeywordsControlled drug delivery, Drug delivery strategies, drug delivery system, Drug Delivery Systems, Drug Liberation, drug release, Electric conductivity, Few-layer graphene, Graphene, Graphite, Hybrid hydrogels, hydrogel, Hydrogels, Mechanical stability, Mechanical stimulus, Oxidation process, Polymeric matrices, Scaffolds (biology), Targeted drug delivery, Temperature, Therapeutic treatments, Triggered drug release

The synthesis of graphene-based materials has attracted considerable attention in drug delivery strategies. Indeed, the conductivity and mechanical stability of graphene have been investigated for controlled and tunable drug release via electric or mechanical stimuli. However, the design of a thermo-sensitive scaffold using pristine graphene (without distortions related to the oxidation processes) has not been deeply investigated yet, although it may represent a promising approach for several therapeutic treatments. Here, few-layer graphene was used as a nanofiller in a hydrogel system with a thermally tunable drug release profile. In particular, varying the temperature (25 °C, 37 °C and 44 °C), responsive drug releases were noticed and hypothesized depending on the formation and perturbation of π-π interactions involving graphene, the polymeric matrix and the model drug (diclofenac). As a result, these hybrid hydrogels show a potential application as thermally triggered drug release systems in several healthcare scenarios. © 2020 Elsevier B.V.


cited By 2

Citation KeyMauri2021