Necroptosis in intestinal inflammation and cancer: New concepts and therapeutic perspectives

TitleNecroptosis in intestinal inflammation and cancer: New concepts and therapeutic perspectives
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2020
AuthorsNegroni, Anna, Colantoni E., Cucchiara S., and Stronati Laura
JournalBiomolecules
Volume10
Start Page1431
Issue10
Pagination1-20
Type of Articlereview
ISSN2218273X
Abstract

Necroptosis is a caspases-independent programmed cell death displaying intermediate features between necrosis and apoptosis. Albeit some physiological roles during embryonic development such tissue homeostasis and innate immune response are documented, necroptosis is mainly considered a pro-inflammatory cell death. Key actors of necroptosis are the receptor-interacting-protein-kinases, RIPK1 and RIPK3, and their target, the mixed-lineage-kinase-domain-like protein, MLKL. The intestinal epithelium has one of the highest rates of cellular turnover in a process that is tightly regulated. Altered necroptosis at the intestinal epithelium leads to uncontrolled microbial translocation and deleterious inflammation. Indeed, necroptosis plays a role in many disease conditions and inhibiting necroptosis is currently considered a promising therapeutic strategy. In this review, we focus on the molecular mechanisms of necroptosis as well as its involvement in human diseases. We also discuss the present developing therapies that target necroptosis machinery. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85092458823&doi=10.3390%2fbiom10101431&partnerID=40&md5=7a7daaa420251fa4ea53606d34f71288
DOI10.3390/biom10101431