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Hyaluronic Acid Nanoporous Microparticles with Long In Vivo Joint Residence Time and Sustained Release

TitleHyaluronic Acid Nanoporous Microparticles with Long In Vivo Joint Residence Time and Sustained Release
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2017
AuthorsPalmieri, G., Rinaldi Antonio, Campagnolo L., Tortora M., Caso M.F., Mattei M., Notargiacomo A., Rosato N., Bottini M., and Cavalieri F.
JournalParticle and Particle Systems Characterization
Volume34
ISSN09340866
Keywordsbiocompatibility, Cross linking agents, Crosslinking, enzymatic degradation, Hyaluronic acid, Intra-articular injection, Joints (anatomy), Micro-particles, Microsponges, Nano-porous, Organic acids, Physiological condition, Sustained release
Abstract

A simple approach is reported to engineer biodegradable and biocompatible nanoporous hyaluronic acid particles (NPHAs) with a characteristic sponge-like morphology and uniform size. These NPHAs can be synthesized using the concomitant cross-linking of hyaluronic acid and the cross-linking agent precipitation. The nanoporous architecture of NPHAs prevents the rapid enzymatic degradation of hyaluronic acid and controls the erosion of microparticles in physiological conditions. Once injected into an intra-articular body cavity of healthy mice, these NPHAs reside at the point-of-delivery for an extended time period, exhibiting a sustained release of hyaluronic acid. In addition, in vivo studies indicate the persistence of NPHAs in the knee joints with neither accumulation into major organs, nor any local or systemic side-effect. The use of NPHAs is emphasized as reservoirs of hyaluronic acid, effectively providing an innovative and safe platform for prolonging the favorable effects displayed by hyaluronic acid on joints affected by osteoarthritis. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Notes

cited By 5

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85017413793&doi=10.1002%2fppsc.201600411&partnerID=40&md5=32f9417091f9c328f96a1efffbe70eec
DOI10.1002/ppsc.201600411
Citation KeyPalmieri2017