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Radicinin, a fungal phytotoxin as a target-specific bioherbicide for invasive buffelgrass (cenchrus ciliaris) control

TitleRadicinin, a fungal phytotoxin as a target-specific bioherbicide for invasive buffelgrass (cenchrus ciliaris) control
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2019
AuthorsMasi, M., Freda F., Sangermano F., Calabrò V., Cimmino A., Cristofaro M., Meyer S., and Evidente A.
JournalMolecules
Volume24
ISSN14203049
Keywordsanimal, Animals, benzaldehyde derivative, Benzaldehydes, Cenchrus, drug effect, Embryo, fatty alcohol, Fatty Alcohols, herbicide, Herbicides, immunology, Nonmammalian, nonmammalian embryo, pyriculol, pyrone derivative, Pyrones, radicinin, zebra fish, Zebrafish
Abstract

The fungal pathogens Cochliobolus australiensis and Pyricularia grisea have recently been isolated from diseased leaves of buffelgrass (Cenchrus ciliaris) in its North American range, and their ability to produce phytotoxic metabolites that could potentially be used as natural herbicides against this invasive weed was investigated. Fourteen secondary metabolites obtained from in vitro cultures of these two pathogens were tested by leaf puncture assay on the host plant at different concentrations. Radicinin and (10S, 11S)-epi-pyriculol proved to be the most promising compounds. Thus, their phytotoxic activity was also evaluated on non-host indigenous plants. Radicinin demonstrated high target-specific toxicity on buffelgrass, low toxicity to native plants, and no teratogenic, sub-lethal, or lethal effects on zebrafish (Brachydanio rerio) embryos. It is now under consideration for the development of a target-specific bioherbicide to be used against buffelgrass in natural systems where synthetic herbicides cause excessive damage to native plants. © 2019 by the authors.

Notes

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85063114293&doi=10.3390%2fmolecules24061086&partnerID=40&md5=f9d2f583abf503c1833e872f4eb1f993
DOI10.3390/molecules24061086
Citation KeyMasi2019