Semen Quality and Sperm DNA Integrity in Patients With Severe Active Inflammatory Bowel Disease and Effects of Tumour Necrosis Factor-alpha Inhibitors

TitleSemen Quality and Sperm DNA Integrity in Patients With Severe Active Inflammatory Bowel Disease and Effects of Tumour Necrosis Factor-alpha Inhibitors
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2019
AuthorsGrosen, A., Bungum M., Christensen L.A., Cordelli Eugenia, Larsen O.H., Leter Giorgio, Julsgaard M., Vestergaard T., Villani P., Hvas C.L., and Kelsen J.
JournalJournal of Crohn's & colitis
Volume13
Pagination564-571
ISSN18764479
Abstract

{BACKGROUND AND AIMS: The impact of severe inflammation on semen quality, including sperm DNA integrity, in men with inflammatory bowel disease [IBD] is unknown, as are the potential effects of anti-tumour necrosis factor-alpha [TNF-alpha] therapy. We investigated the influence of severe active IBD and anti-TNF-alpha treatment on semen quality. METHODS: We prospectively included 20 patients admitted with severe active IBD. Further, 19 patients who initiated and 17 who stopped anti-TNF-alpha therapy were included. Semen samples were obtained during active disease, and on/off treatment. For paired comparisons, samples were collected not less than 3 months after achieving remission, after treatment initiation, or after treatment cessation. Sperm DNA Fragmentation Index [DFI], concentration, morphology, and motility were evaluated. Sex hormones and seminal plasma anti-TNF-alpha drug levels were measured. RESULTS: In patients with severe disease, progressive sperm motility was impaired and increased significantly [from 28.4% to 37.4%

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85067802028&doi=10.1093%2fecco-jcc%2fjjy198&partnerID=40&md5=cf20d070fa295b2ee8d14d3ee8748dd0
DOI10.1093/ecco-jcc/jjy198