| Title | Sperm DNA Integrity is Unaffected by Thiopurine Treatment in Men With Inflammatory Bowel Disease |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2019 |
| Authors | Grosen, A., Nersting J., Bungum M., Christensen L.A., Schmiegelow K., Spanò M., Julsgaard M., Cordelli Eugenia, Leter Giorgio, Larsen P.B., Hvas C.L., and Kelsen J. |
| Journal | Journal of Crohn's & colitis |
| Volume | 13 |
| Pagination | 3-11 |
| ISSN | 18764479 |
| Abstract | {Background and Aims: Sperm DNA integrity, concentration, and motility are suspected to be altered by thiopurines (azathioprine [AZA] and 6-mercaptopurine [6-MP]). We investigated the impact of thiopurines on semen quality in men with inflammatory bowel disease [IBD], by a comprehensive panel of semen analyses. Methods: Semen from 40 men with IBD, in remission on AZA/6-MP therapy, was prospectively collected and compared with samples from 40 healthy volunteers. Paired samples [off and on AZA/6-MP] were obtained from a subset of IBD patients, and blood and semen were collected to determine 6-MP transmission to the ejaculate. Sperm DNA fragmentation was evaluated via sperm chromatin structure assay [SCSA] and Comet analysis. Conventional World Health Organization [WHO] parameters, i.e. semen volume and sperm concentration, motility, and morphology, were assessed. Additionally, we measured thioguanine nucleotide [TGN] incorporation in sperm cell DNA. Results: Sperm DNA fragmentation levels did not differ between men with IBD on AZA/6-MP and healthy volunteers when evaluated by SCSA [p = 0.23] and Comet analysis [p = 0.72]. IBD patients on AZA/6-MP had significantly lower total and progressive sperm motility than healthy volunteers [48.5% versus 64.5% |
| Notes | cited By 0 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058915498&doi=10.1093%2fecco-jcc%2fjjy086&partnerID=40&md5=a0b7c7492e9e84ee7acc014cc9f11a02 |
| DOI | 10.1093/ecco-jcc/jjy086 |
| Citation Key | Grosen20193 |
