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Asbestos-related lung cancer mortality in Piedmont, Italy

TitleAsbestos-related lung cancer mortality in Piedmont, Italy
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication1998
AuthorsMartuzzi, M., Comba P., De Santis M., Iavarone I., Di Paola M., Mastrantonio Marina, and Pirastu R.
JournalAmerican Journal of Industrial Medicine
Volume33
Pagination565-570
ISSN02713586
Keywordsadult, aged, altitude, article, Asbestos, asbestosis, Bayes Theorem, cancer mortality, cause of death, Confidence Intervals, environmental exposure, human, Humans, Italy, lung cancer, Lung Neoplasms, major clinical study, male, Middle Aged, pleura tumor, Pleural Neoplasms, Poisson Distribution, risk, rural population, Urban Population, urban rural difference
Abstract

This study investigates the association between pleural neoplasm mortality, a possible proxy for asbestos exposure, and lung cancer mortality among males resident in Piedmont (northwestern Italy). Pleural neoplasm mortality was estimated in the 1,209 municipalities of the region for the period 1980-1992, applying Bayesian methods. The association with lung cancer mortality for municipalities was studied using Poisson regression. Urban/rural indicators and altitude were also included in the analysis. A positive, statistically significant association was found between pleural neoplasm and lung cancer mortality (β = 0.025, P < 0.001); lung cancer risk was associated also with urban status (vs. rural, β = 0.223, P < 0.001) and altitude (P = 0.01). The proportion of lung cancer deaths attributable to living in municipalities with increased pleural neoplasm mortality was 3.9% (95% confidence interval, 2.1-5.7%). The observed association and the presence of a dose-response relationship at the municipality level underscore the dangers of asbestos for human health.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0031831925&doi=10.1002%2f%28SICI%291097-0274%28199806%2933%3a6%3c565%3a%3aAID-AJIM7%3e3.0.CO%3b2-P&partnerID=40&md5=f5723a2ec3ede028d005662daa97f991
DOI10.1002/(SICI)1097-0274(199806)33:6<565::AID-AJIM7>3.0.CO;2-P
Citation KeyMartuzzi1998565