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Nanosecond pulsed electric field (nsPEF): A microdosimetry study at single cell level

TitleNanosecond pulsed electric field (nsPEF): A microdosimetry study at single cell level
Publication TypePresentazione a Congresso
Year of Publication2009
AuthorsMerla, Caterina, Paffi A., Liberti M., Apollonio F., Danei F., Leveque P., and d'Inzeo G.
Conference NameProceedings of the 2009 International Conference on Electromagnetics in Advanced Applications, ICEAA '09
Keywordscell culture, Cell lines, Dielectric membranes, Electric fields, electromagnetism, electroporation, Membrane Potentials, Micro-dosimetry, Microdosimetric study, Nanosecond pulsed electric fields, Number distribution, Quasi-static, Single-cell level, Spherical cells
Abstract

Exposure of cell lines and tissues to nanosecond pulsed electric fields has been associated to a number of biological relevant phenomena, suggesting the plasmatic membrane as one of the main interaction targets. In this context, a microdosimetric study able to predict trans-membrane potential and pore number distribution on the membrane seems to be particularly interesting. Thus to obtain these quantities, a quasi-static electromagnetic solution coupled with and asymptotic electroporation model is solved on a three-layered spherical cell. Consequently the role played by including or disregarding Debye description as well as by adopting different dielectric membrane models on such observables is discussed. © 2009 IEEE.

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-72849135968&doi=10.1109%2fICEAA.2009.5297324&partnerID=40&md5=9ef578848262f1c3ad24d37ebc0c449e
DOI10.1109/ICEAA.2009.5297324
Citation KeyMerla2009909