| Title | Effects of nanosecond pulsed electric fields on the activity of a Hodgkin and Huxley neuron model |
|---|---|
| Publication Type | Presentazione a Congresso |
| Year of Publication | 2012 |
| Authors | Camera, F., Paffi A., Merla Caterina, Denzi A., Apollonio F., Marracino P., d'Inzeo G., and Liberti M. |
| Conference Name | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
| Keywords | Action potentials, Biological effects, Cell membranes, Chronic pain, cytology, Electric fields, Electric stimulation, Electrical activities, Electrophysiology, Electrotherapeutics, Inhibition time, Medical applications, Nanosecond pulsed electric fields, Neuron model, Neuronal activities, Neurons, Stimulation techniques, Structural change, Time varying, Time-periods |
| Abstract | The cell membrane poration is one of the main assessed biological effects of nanosecond pulsed electric fields (nsPEF). This structural change of the cell membrane appears soon after the pulse delivery and lasts for a time period long enough to modify the electrical activity of excitable membranes in neurons. Inserting such a phenomenon in a Hodgkin and Huxley neuron model by means of an enhanced time varying conductance resulted in the temporary inhibition of the action potential generation. The inhibition time is a function of the level of poration, the pore resealing time and the background stimulation level of the neuron. Such results suggest that the neuronal activity may be efficiently modulated by the delivery of repeated pulses. This opens the way to the use of nsPEFs as a stimulation technique alternative to the conventional direct electric stimulation for medical applications such as chronic pain treatment. © 2012 IEEE. |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870855708&doi=10.1109%2fEMBC.2012.6346488&partnerID=40&md5=9da1f2cd7c783cd8321ddebcdcc5523e |
| DOI | 10.1109/EMBC.2012.6346488 |
| Citation Key | Camera20122567 |
