Sorry, you need to enable JavaScript to visit this website.

Cell detection by a microfluidic-integrated broadband biosensor

TitleCell detection by a microfluidic-integrated broadband biosensor
Publication TypePresentazione a Congresso
Year of Publication2014
AuthorsMultari, C., Ning Y., Luo X., Palego C., Denzi A., Merla Caterina, Apollonio F., Liberti M., Hwang J.C.M., and Cheng X.
Conference NameTechnical Proceedings of the 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014
KeywordsBiosensors, Broadband, Cell membranes, Cells, cytology, Electrical sensors, Impedance sensors, Low frequency range, Mammalian cells, Mammals, Medical nanotechnology, Micro-fluidic devices, Microfluidics, Monitoring purpose, nanotechnology, Photonics, Sensor performance
Abstract

Detection of identity, quantity and viability of cells at the point-of-need is critically needed for diagnostic, surveillance and monitoring purposes. In this work, we present a broadband electrical sensor combined with a microfluidic device to detect mammalian cells and bacteria. It is found that the device can detect down to single mammalian cells in a suspension. The device is also capable of differentiating cells based on their viability and size. With a specific cell type, cell number can be obtained through signal analysis. Compared to conventional impedance sensors that operate in narrow and low frequency ranges, this device not only detects the properties of cell membranes in the MHz range, but also the intracellular environment in the GHz range, thus revealing richer information about the cell identity and function. Ongoing research intends to optimize the sensor performance to extract biochemical signature from cells.

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84907391015&partnerID=40&md5=3f8476dd749eacd00e41d203d54dc9ef
Citation KeyMultari2014101