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A microdosimetry study for a realistic shaped nucleus

TitleA microdosimetry study for a realistic shaped nucleus
Publication TypePresentazione a Congresso
Year of Publication2016
AuthorsDenzi, A., Escobar J.A.A., Nasta C., Merla Caterina, Benassi Barbara, Consales Claudia, Apollonio F., and Liberti M.
Conference NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
PublisherInstitute of Electrical and Electronics Engineers Inc.
Keywordsalgorithm, Algorithms, Cell Line, Cell Nucleus, Electricity, electroporation, human, Humans, physiology, radiometry, Tumor, tumor cell line
Abstract

In the last decades, the effects of ultrashort pulsed electric fields have been investigated demonstrating their capability to be involved in a great number of medical applications (e.g. cancer, gene electrotransfer, drug delivery, electrofusion). In particular, experiments in literature demonstrate that internal structures can be involved when pulse duration is reduced. Up to now, the mechanism that permits the electroporation phenomenon has not been completely understood and hence atomistic, microdosimetry and dosimetry models have been developed to help in this field. Aim of this work is to demonstrate the importance of realistically model also the internal organelles to obtain predictive results of effects at sub-cellular level with a microdosimetry model. © 2016 IEEE.

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85009121764&doi=10.1109%2fEMBC.2016.7591650&partnerID=40&md5=77170e1cd2ea1f51c99b2cd79561e27f
DOI10.1109/EMBC.2016.7591650
Citation KeyDenzi20164189