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Inhibition of both skin and lung tumorigenesis by Car-R mouse-derived cancer modifier loci

TitleInhibition of both skin and lung tumorigenesis by Car-R mouse-derived cancer modifier loci
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2002
AuthorsSaran, Anna, Zaffaroni D., Pazzaglia Simonetta, Peissel B., Galbiati F., Spinola M., Manenti G., Zanesi N., Rebessi S., Mancuso Mariateresa, Covelli V., and Dragani T.A.
JournalInternational Journal of Cancer
KeywordsAlleles, animal experiment, Animals, article, Breeding, cancer resistance, cancer risk, Carcinogenicity Tests, Carcinogens, Experimental, Female, gene locus, Genetic, Genetic Predisposition to Disease, Inbred Strains, Inbreeding, Incidence, lung cancer, lung carcinogenesis, Lung Neoplasms, male, Mice, mouse, Neoplasms, nonhuman, Outbred Strains, papilloma, Phenotype, Polymerase Chain Reaction, Polymorphism, priority journal, Proto-Oncogene Proteins, skin cancer, skin carcinogenesis, Skin Neoplasms, Tetradecanoylphorbol Acetate, Urethane

The Car-R outbred mouse line was phenotypically selected for high resistance to two-stage skin tumorigenesis. In the present study we tested the hypothesis that a subset of genetic loci responsible for resistance to skin tumorigenesis of Car-R mice might also inhibit lung tumorigenesis. Skin and lung tumorigenesis were induced in groups of Car-R, SWR/J, (SWR/JxCar-R)FI and SWR/Jx(SWR/JxCar-R) backcross mice by i.p. urethane initiation and skin TPA promotion. Car-R mice showed a much lower susceptibility to both skin and lung tumorigenesis as compared to SWR/J mice, which are susceptible to both lung and skin tumorigenesis. The Car-R-inherited genome significantly inhibited both skin and lung cancer development in the FI progeny of Car-R with SWR/J mice. In the backcross population, skin and lung tumor phenotypes showed a statistically significant correlation, indicating that a subset of the cancer resistance alleles, which segregated in the Car-R line during selection for resistance to skin carcinogenesis, provides resistance to both skin and lung tumorigenesis. © 2002 Wiley-Liss, Inc.


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Citation KeySaran2002580