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Anti-inflammatory drug incorporation into polymeric nano-hybrids for local controlled release.

TitleAnti-inflammatory drug incorporation into polymeric nano-hybrids for local controlled release.
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2005
AuthorsSammartino, G., Marenzi G., Tammaro Loredana, Bolognese A., Calignano A., Costantino U., Califano L., Mastrangelo F., Tetè S., and Vittoria V.
JournalInternational journal of immunopathology and pharmacology
Volume18
Pagination55-62
KeywordsAnti-Inflammatory Agents, article, biomechanics, chemistry, delayed release formulation, Delayed-Action Preparations, Diclofenac, nanocomposite, Nanocomposites, Non-Steroidal, nonsteroid antiinflammatory agent, Pharmaceutical, polymer, Polymers, thermogravimetry, X ray diffraction, X-Ray Diffraction
Abstract

In this paper we present the formulation, preparation and characterization of new polymeric composite materials containing a nano-hybrid to be used for the controlled molecular delivery of an anti-inflammatory molecule, Diclofenac. The nano-hybrid consists of a layer of double hydroxide of an Mg-Al hydrotalcite type, in which we replaced the chloride anions present in the host galleries with Diclofenac anions by a simple ion-exchange reaction. Different amounts of the hybrid material were incorporated in polycaprolactone and processed as films of 0.15 mm thickness. The composite materials were analyzed by X-ray diffractometry, thermogravimetry and for their mechanical properties, and showed properties even better than those for the pristine polymer. The release process of the anti-inflammatory molecules was very interesting and promising for tuneable drug delivery. It consists of two stages: a first stage, very rapid as a burst in which a small fraction of the drug is released, and of a second stage that is much slower, extending for longer and longer periods. The parameters influencing the drug release were individuated and discussed.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-41649121173&partnerID=40&md5=717e1fca24faf9fc6b78d5fc4941f7c5
Citation KeySammartino200555