| Title | An E7-based therapeutic vaccine protects mice against HPV16 associated cancer |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2009 |
| Authors | Venuti, A., Massa Silvia, Mett V., Vedova L.D., Paolini F., Franconi Rosella, and Yusibov V. |
| Journal | Vaccine |
| Volume | 27 |
| Pagination | 3395-3397 |
| ISSN | 0264410X |
| Keywords | animal cell, animal experiment, animal model, Animals, antineoplastic activity, article, cancer immunization, cancer inhibition, cancer survival, cancer vaccine, Clostridium thermocellum, controlled study, dosage schedule comparison, drug purification, drug synthesis, Experimental, Female, glucan glucosidase, Human papillomavirus type 16, Inbred C57BL, LicKM E7GGG vaccine, Mice, mouse, Neoplasm Transplantation, Neoplasms, Nicotiana benthamiana, nonhuman, Oncogene Proteins, Papillomavirus Infections, Papillomavirus Vaccines, priority journal, protein E7, provocation test, Synthetic, Tobacco, tumor growth, unclassified drug, uterine cervix cancer, vaccination, Vaccines, Viral |
| Abstract | Plant-derived vaccines represent an attractive strategy for cancer immunotherapy due to their relative safety and cost-effectiveness. We evaluated the anti-tumour activity of a Nicotiana benthamiana produced vaccine candidate based on the non-transforming E7 protein of HPV-16 fused to β-1,3-1,4-glucanase of Clostridium thermocellum. Two doses of vaccine at two week intervals were administered to groups of C57BL/6 mice starting 3 or 6 days after challenge with tumourigenic E7-expressing TC-1* cells. Inhibition of tumour growth and increased survival was observed in both groups treated with vaccine. These data suggest the potential of plants as a platform for producing therapeutic vaccines. © 2009 Elsevier Ltd. All rights reserved. |
| Notes | cited By 29 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-67349204308&doi=10.1016%2fj.vaccine.2009.01.068&partnerID=40&md5=be8a57c9df4704859b9ee6b108df6a54 |
| DOI | 10.1016/j.vaccine.2009.01.068 |
| Citation Key | Venuti20093395 |
