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Scanning Small- and Wide-Angle X-ray Scattering Microscopy Selectively Probes HA Content in Gelatin/Hydroxyapatite Scaffolds for Osteochondral Defect Repair

TitleScanning Small- and Wide-Angle X-ray Scattering Microscopy Selectively Probes HA Content in Gelatin/Hydroxyapatite Scaffolds for Osteochondral Defect Repair
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2016
AuthorsAltamura, D., Pastore S.G., Raucci M.G., Siliqi D., De Pascalis F., Nacucchi Michele, Ambrosio L., and Giannini C.
JournalACS Applied Materials and Interfaces
Volume8
Pagination8728-8736
ISSN19448244
Abstract

This study is aimed at investigating the structure of a scaffold made of bovine gelatin and hydroxyapatite for bone tissue engineering purposes. In particular, the detailed characterization of such a material has a great relevance because of its application in the healing process of the osteochondral defect that consists of a damage of cartilage and injury of the adjacent subchondral bone, significantly compromising millions of patient's quality of life. Two different techniques exploiting X-ray radiation, with table-top setups, are used: microtomography (micro-CT) and microdiffraction. Micro-CT characterizes the microstructure in the three dimensions at the micrometer scale spatial resolution, whereas microdiffraction provides combined structural/morphological information at the atomic and nanoscale, in two dimensional microscopy images with a hundred micrometer spatial resolution. The combination of these two techniques allowed an appropriate structural characterization for the purpose of validating the engineering approach used for the realization of the hydroxyapatite gradient across the scaffold, with properties close to the natural model. © 2016 American Chemical Society.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84964787428&doi=10.1021%2facsami.6b00557&partnerID=40&md5=01bf92cfbe4da2ba66d94a7ac7ff620d
DOI10.1021/acsami.6b00557
Citation KeyAltamura20168728