| Title | Effect of recombinant il‐3 on lymphocyte populations in irradiated mice |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 1993 |
| Authors | Doria, G., Leter Giorgio, Mancini C., and Frasca D. |
| Journal | STEM CELLS |
| Volume | 11 |
| Pagination | 93-97 |
| ISSN | 10665099 |
| Keywords | animal, animal cell, animal experiment, animal model, CD4 antigen, CD8 antigen, Cell Count, cell differentiation, concanavalin a, conference paper, controlled study, drug effect, hematopoiesis, Inbred C57BL, Inbred DBA, Interleukin-3, irradiation, lipopolysaccharide, Lipopolysaccharides, lymphocyte activation, lymphocyte subpopulation, Lymphocyte Subsets, male, Mice, mitosis, mouse, nonhuman, recombinant interleukin 3, Recombinant Proteins, spleen cell, subcutaneous drug administration, thymocyte, Whole-Body Irradiation |
| Abstract | Administration of murine recombinant interleukin 3 (IL‐3) to sublethally irradiated mice induced in the thymus recovery of the cell count and mitotic responsiveness to Con A, as well as a decrease in CD4−CD8− cells concomitant with an increase in single positive cells. Also in the spleen, the cell count and mitotic responsiveness to Con A and lipopolysaccharide (LPS) were recovered by IL‐3 treatment. These findings show that IL‐3 induces differentiation and growth of thymocytes and recovery of T and B cell functions in sublethally irradiated mice. Copyright © 1993 AlphaMed Press |
| Notes | cited By 0 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027377903&doi=10.1002%2fstem.5530110816&partnerID=40&md5=013c02b76170c99bc4c349ad58536c91 |
| DOI | 10.1002/stem.5530110816 |
| Citation Key | Doria199393 |
