| Title | Clonal expansion precedes anergy and death of V beta 8+ peripheral T cells responding to staphylococcal enterotoxin B in vivo. |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 1991 |
| Authors | MacDonald, H R., Baschieri Selene, and Lees R K. |
| Journal | European journal of immunology |
| Volume | 21 |
| Pagination | 1963-6 |
| Date Published | 1991 Aug |
| ISSN | 0014-2980 |
| Keywords | Animals, antigen, Antigens, CD4, CD8, Cell Survival, Differentiation, Enterotoxins, Female, Inbred BALB C, Interleukin-2, Mice, Receptors, Staphylococcus aureus, T-Cell, T-Lymphocyte, T-Lymphocytes |
| Abstract | Staphylococcal enterotoxin B (SEB) selectively stimulates T cells bearing T cell receptor V beta 8 domains and hence provides a useful model to study immunity and tolerance in vivo. We show here that V beta 8+ T cells in both CD4+ and CD8+ subsets expand dramatically (fivefold) in lymphoid tissues of mice 2-4 days following injection with SEB. This initial clonal expansion, which is accompanied by a transient hyper-reactivity to SEB, is followed by a rapid decrease in V beta 8+ cells and a concomitant induction of specific non-responsiveness which persists for at least 30 days. Selective death of V beta 8+ cells occurs during this latter phase. Taken together, our data indicate that clonal expansion, anergy and death can occur as sequential stages of an immune response in vivo. |
| Notes | cited By 276 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025767045&doi=10.1002%2feji.1830210827&partnerID=40&md5=ee264bc6ab24791e7e5fcb30b521144c |
| DOI | 10.1002/eji.1830210827 |
| Citation Key | 5424 |
