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Clinical use and molecular action of corticosteroids in the pediatric age

TitleClinical use and molecular action of corticosteroids in the pediatric age
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2019
AuthorsFerrara, Giovanna, Petrillo Maria Grazia, Giani Teresa, Marrani Edoardo, Filippeschi Cesare, Oranges Teresa, Simonini Gabriele, and Cimaz Rolando
JournalInternational Journal of Molecular Sciences
Type of ArticleReview
Keywordsacetylsalicylic acid, adolescent, age, Age Factors, Anti-Inflammatory Agents, antigen presenting cell, antiinflammatory agent, Child, childhood disease, clinical trial (topic), Clinical Trials as Topic, corticosteroid, Cushingoid syndrome, cytochrome P450 1A2, cytokine, DNA binding, DNA transcription, drug mechanism, drug megadose, endocrine disease, gastrointestinal disease, gene, Genomics, glucocorticoid, glucocorticoid receptor, glucocorticoid receptor alpha, Glucocorticoids, growth retardation, hematologic disease, Hormone Replacement Therapy, hormone substitution, human, Humans, hypercortisolism, immune response, Immunoglobulin, immunologic factor, Immunologic Factors, immunoregulation, Infant, juvenile dermatomyositis, juvenile rheumatoid arthritis, kidney disease, metabolic disorder, metabolism, methylprednisolone, mucocutaneous lymph node syndrome, neurologic disease, newborn, physiology, prednisone, Preschool, preschool child, RANTES, Receptors, respiratory tract disease, review, rheumatic fever, scleroderma, skin disease, systemic lupus erythematosus, Th1 Th2 balance, treatment outcome, upregulation, uveitis, vasculitis

Corticosteroids are the mainstay of therapy for many pediatric disorders and sometimes are life-saving. Both endogenous and synthetic derivatives diffuse across the cell membrane and, by binding to their cognate glucocorticoid receptor, modulate a variety of physiological functions, such as glucose metabolism, immune homeostasis, organ development, and the endocrine system. However, despite their proved and known efficacy, corticosteroids show a lot of side effects, among which growth retardation is of particular concern and specific for pediatric age. The aim of this review is to discuss the mechanism of action of corticosteroids, and how their genomic effects have both beneficial and adverse consequences. We will focus on the use of corticosteroids in different pediatric subspecialties and most common diseases, analyzing the most recent evidence. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.


Cited by: 47; All Open Access, Gold Open Access, Green Open Access

Citation KeyFerrara2019
PubMed ID30669566