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Carotenoid biofortification in crop plants: citius, altius, fortius

TitleCarotenoid biofortification in crop plants: citius, altius, fortius
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2020
AuthorsZheng, X., Giuliano Giovanni, and Al-Babili S.
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
KeywordsAntioxidant, Antioxidants, biofortification, biosynthesis, carotene, Carotenoid, Carotenoids, chemistry, Crop, Gene editing, Genetic engineering, genetics, human, Humans, isoprenoid, lipid metabolism, metabolic engineering, metabolism, nonhuman, photosynthesis, Plant, priority journal, provitamin, Provitamins, retinol, review, Vitamin A, vitamin metabolism, xanthophyll

Carotenoids are indispensable for human health, required as precursors of vitamin A and efficient antioxidants. However, these plant pigments that play a vital role in photosynthesis are represented at insufficient levels in edible parts of several crops, which creates a need for increasing their content or optimizing their composition through biofortification. In particular, vitamin A deficiency, a severe health problem affecting the lives of millions in developing countries, has triggered the development of a series of high-provitamin A crops, including Golden Rice as the best-known example. Further carotenoid-biofortified crops have been generated by using genetic engineering approaches or through classical breeding. In this review, we depict carotenoid metabolism in plants and provide an update on the development of carotenoid-biofortified plants and their potential to meet needs and expectations. Furthermore, we discuss the possibility of using natural variation for carotenoid biofortification and the potential of gene editing tools. This article is part of a Special Issue entitled Carotenoids recent advances in cell and molecular biology edited by Johannes von Lintig and Loredana Quadro. © 2020 Elsevier B.V.


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Citation KeyZheng2020