Sorry, you need to enable JavaScript to visit this website.

Engineering Metabolism in Nicotiana Species: A Promising Future

TitleEngineering Metabolism in Nicotiana Species: A Promising Future
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2021
AuthorsMolina-Hidalgo, F.J., Vazquez-Vilar M., D'Andrea L., Demurtas Olivia Costantina, Fraser P., Giuliano Giovanni, Bock R., Orzáez D., and Goossens A.
JournalTrends in Biotechnology
KeywordsActive pharmaceutical ingredients, Agricultural, bioeconomy, Biofactories, Biotechnological tools, Biotechnology, Crop, Crop plants, Crops, Gene editing, genetics, High yield, human, metabolic engineering, Metabolic versatility, metabolism, Molecular farming, Nicotiana, Non-food crops, nonhuman, Plant breeding, procedures, review, synthetic biology, Tobacco

Molecular farming intends to use crop plants as biofactories for high value-added compounds following application of a wide range of biotechnological tools. In particular, the conversion of nonfood crops into efficient biofactories is expected to be a strong asset in the development of a sustainable bioeconomy. The ‘nonfood’ status combined with the high metabolic versatility and the capacity of high-yield cultivation highlight the plant genus Nicotiana as one of the most appropriate ‘chassis’ for molecular farming. Nicotiana species are a rich source of valuable industrial, active pharmaceutical ingredients and nutritional compounds, synthesized from highly complex biosynthetic networks. Here, we review and discuss approaches currently used to design enriched Nicotiana species for molecular farming using new plant breeding techniques (NPBTs). © 2020 Elsevier Ltd


cited By 6

Citation KeyMolina-Hidalgo2021901