| Title | Engineering Metabolism in Nicotiana Species: A Promising Future |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2021 |
| Authors | Molina-Hidalgo, F.J., Vazquez-Vilar M., D'Andrea L., Demurtas Olivia Costantina, Fraser P., Giuliano Giovanni, Bock R., Orzáez D., and Goossens A. |
| Journal | Trends in Biotechnology |
| Volume | 39 |
| Pagination | 901-913 |
| ISSN | 01677799 |
| Keywords | Active pharmaceutical ingredients, Agricultural, bioeconomy, Biofactories, Biotechnological tools, Biotechnology, Crop, Crop plants, Crops, Gene editing, genetics, High yield, human, metabolic engineering, Metabolic versatility, metabolism, Molecular farming, Nicotiana, Non-food crops, nonhuman, Plant breeding, procedures, review, synthetic biology, Tobacco |
| Abstract | Molecular farming intends to use crop plants as biofactories for high value-added compounds following application of a wide range of biotechnological tools. In particular, the conversion of nonfood crops into efficient biofactories is expected to be a strong asset in the development of a sustainable bioeconomy. The ‘nonfood’ status combined with the high metabolic versatility and the capacity of high-yield cultivation highlight the plant genus Nicotiana as one of the most appropriate ‘chassis’ for molecular farming. Nicotiana species are a rich source of valuable industrial, active pharmaceutical ingredients and nutritional compounds, synthesized from highly complex biosynthetic networks. Here, we review and discuss approaches currently used to design enriched Nicotiana species for molecular farming using new plant breeding techniques (NPBTs). © 2020 Elsevier Ltd |
| Notes | cited By 6 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097907839&doi=10.1016%2fj.tibtech.2020.11.012&partnerID=40&md5=8e2b77127c84dff54002cf5a744b1a78 |
| DOI | 10.1016/j.tibtech.2020.11.012 |
| Citation Key | Molina-Hidalgo2021901 |
